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Two new diabetes drug targets identified

Scientists at Penn and Howard Hughes Medical Institute believe that their investigation of the role fat metabolism plays in the development of Type 2 diabetes has pointed to a new drug target. Their focus is a protein that plays a role in fat metabolism. The protein Akt2/PKB prevents fat metabolism by adding a phosphate group to PGC-1a, which is needed to trigger the genes needed for fat metabolism. Both PGC-1a and Akt2/PKB are good targets for new drug development, according to the …

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