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Computer modeling could help design next-generation antibiotics

A team at the University of Bristol in the U.K. used computer simulations to gain insight into how drug-resistant bacteria are able to ward off antibiotics.

Protein boost restores hearing in deaf mice

Zeroing in on a protein that's vital to providing communication between the ears and brain, scientists have restored hearing in mice that were partly deaf. The researchers say that boosting the production of this protein in humans through gene therapy may be able to one day cure people who have lost part or all of their hearing.

GlaxoSmithKline drug flips off cancer mechanism in aggressive leukemia

Turning off an enzyme switch that is needed to activate tumor growth may be an effective way to combat an aggressive kind of cancer called T-cell acute lymphoblastic leukemia, according to researchers at New York University's Langone Medical Center.

Researchers pinpoint potent anti-obesity compounds

Researchers from the National University of Singapore have identified several potent inhibitors that selectively target FTO, a gene that has been associated with fat mass and obesity in certain people.

Human intestinal organoids grown in mice could help personalize treatments

Researchers have grown human intestinal tissue from pluripotent stem cells and transplanted the living tissue into mice. These so-called organoids could provide a more accurate model for testing drugs designed to work on the intestines as well as help generate intestinal tissue for new treatments.

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FierceCRO

WuXi PharmaTech has struck a deal with the genomics experts at Foundation Medicine, signing on to offer the company's cancer-decoding services to drug developers in its native China.

FiercePharma Manufacturing

Denmark-based Novo Nordisk said on Friday that it had received a subpoena from a U.S. Attorney who wants some info about its manufacturing operations at a plant in Kalundborg. But the company said it really has no idea why.