Many drugs used to treat lung, breast and pancreatic cancers also promote drug resistance and can ultimately spur tumor growth. Now, researchers may be able to predict which individual tumors will metastasize and spread when treated with certain drugs.
Academic research institutions play a crucial role in the drug development process, especially on the preclinical research and drug discovery side, as Big Pharma companies are increasingly cutting back their R&D spending. While many of the research institutions featured here are still doing plenty of basic science research, interest seems to be growing among these universities in repurposing existing drugs or those that never made it into the marketplace because of safety issues.
We've taken a look at some of the best research institutions in the U.S. and ranked by them by their level of funding from the National Institutes of Health, the largest funder of biomedical research in the world. The report highlights some of the important drug discovery research coming out of these universities that FierceBiotech Research covered in 2013, but it is by no means a comprehensive look at every research initiative at these institutions.
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Scientists report that they have replicated a method of growing stem cells from adults using cloning techniques--a discovery that could help propel patient-specific regenerative therapies for a myriad of medical conditions and diseases.
A new antiviral drug may provide an effective way to treat measles in those who have not been vaccinated.
In a 1993 clinical trial of fialuridine--a drug originally designed as a therapy for hepatitis B--5 out of 15 patients died from sudden liver failure. A new study in PLOS Medicine found that mice with humanized livers demonstrate the drug's toxicity.
The ongoing Ebola outbreak in Western Africa underscores the critical need for better global surveillance strategies to combat the emergence of infectious diseases, especially those that have high mortality rates and pose a bioterror threat to countries, according to a new study.
A team of investigators has identified a new class of compounds that could work in a specific protein complex in the brain to provide a safe route toward reversing the devastating symptoms of Alzheimer's.
An experimental vaccine using a novel defense mechanism could eventually help treat sufferers of a common virus that affects more than half of the U.S. population and causes congenital birth defects in some cases.
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