Testing a theory that the molecule that transports proteins from the nucleus of a cell to the cytoplasm is altered in neurodegenerative diseases like multiple sclerosis, investigators say that they have successfully completed an animal study that tested drugs that could block the molecule and perhaps repair nerve cell damage that occurs in MS.
Over the last few years, testing psychedelic drugs against depression and other diseases of the brain has once again grown fashionable in some drug research groups. But now a team from Louisiana State University says that they have preclinical evidence to suggest that one of those drugs in the neurosciences spotlight could work against allergic asthma. Read more >>
GLP-1 treatments have become an important new class of diabetes drugs, offering a new way to control blood sugar among patients. Now a group of researchers at Cornell says it engineered a human probiotic that also had a similar effect in controlling blood glucose levels in rat models for the disease. And a biotech has already snagged the license on this work as they set the stage to try it in humans. Read more >>
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Researchers in the lab of MIT's Robert Langer have created a hydrogel that's designed to be much better than current technologies in getting drugs into patients and straight to where they are targeted.
Investigators at Monash University say they have illuminated some of the mechanisms that IL-37 uses as a natural anti-inflammatory, building on years of lab work that has spotlighted this as a target for a variety of conditions.
Multidrug resistance to the chemotherapies in wide use today is a lethal problem. As patients stop responding to drugs, they become increasingly vulnerable to a deadly assault. Now investigators at The Scripps Research Institute say they have illuminated a key protein that plays a big role in promoting drug resistance, offering a new approach for investigators designing the next generation of new and improved cancer therapies that won't eventually be disarmed.
During childhood, a protein called DENND2B plays a big role in spurring the migration of cells, a condition that fades as well. But now a team at the Montreal Neurological Institute says that they have discovered that the protein also appears to play a part in promoting metastasis.
Two different teams at Columbia and Harvard have independently created neurons out of iPS cells that regulate appetite, offering a new model for investigators who are studying new weight drugs and various elements of weight control.
Investigators at Duke have turned to a new gene-editing tool to come up with a new approach to Duchenne muscular dystrophy that theoretically could apply to a majority of the boys afflicted with the fatal rare disease.
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Health Canada, which has been accused of not providing the public with enough info about quality concerns over the drugs sold there, says it will increase the number of plant inspections it will do and put more information online.
Mallinckrodt will slap down $2.3 billion to buy Ikaria, a privately held drug company and its respiratory med for babies in neonatal ICUs. The deal will help Mallinckrodt grow its hospital drugs business, with a $150 million boost to revenue this year.