Scientists say that they have developed a method to use modified messenger RNA to lengthen telomeres, opening a pathway to countering the effects of aging in cells--a process that might apply to a range of diseases from DMD to diabetes and heart disease.
The cleaving action of the BACE1 enzyme is considered one of the essential steps in creating concentrations of amyloid beta, the toxic proteins found in the brains of Alzheimer's patients. And as a result, as the leading amyloid beta programs foundered in late-stage studies, BACE1 became a prime target in the research community, with Merck leading the way in the clinic with a late-stage therapy.Read more >>
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Building on research into the way in which glial cells called astrocytes store memories, a group of investigators at the Gladstone Institutes has zeroed in on a particular target--A2A adenosine receptors--that could play a role in preventing one of the most devastating symptoms of Alzheimer's. Read more >>
A transatlantic team of researchers says that they have identified a new pathway in the brain that plays a critical role in signaling hypoglycemia. And they add that it's a solid target for drug researchers working in the blockbuster field.
The Florida branch of The Scripps Research Institute is touting some new advances related to Parkinson's disease. Researchers say they have been working on new therapies that can precisely hit pathways critical for the death of brain cells, a hallmark of the disease. And they're now fine tuning their work by focusing on the oral bioavailability of their new drug candidates.
The recent approval of Novartis' Cosentyx marks the first in a whole new lineup of psoriasis drugs coming into the market. But there's still no cure and only a hazy understanding of the root causes of psoriasis. But scientists at Case Western Reserve say they've identified four proteins that they believe may contribute to the disease.
A team at UC San Diego says that Protein Kinase C (PKC) enzymes, long believed to spur tumor development, are in fact tumor suppressors.
Pancreatic cancer has long loomed as one of the most aggressive killers, typically leaving patients with a poor prognosis and specialists with few options for effective treatment. But now a team at the University of Michigan in Ann Arbor says they have new reason to believe that a particular gene is responsible for the fast-spreading cancer--offering a clear target for drug developers.
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European regulators have joined the FDA in suggesting joint plant inspections and training with their Indian counterparts. The offers come as India's industry has lost status in recent years as the FDA and other countries have banned Indian plants from shipping to the U.S. and Europe over quality and data-integrity issues.
The European Commission has cleared GlaxoSmithKline's deal for most of Novartis' vaccines unit--on a couple of conditions.