CRUK scientists ID a key player behind the spread of breast cancer cells

The interaction between breast cancer cells and a receptor protein called EPHA2 helps explain how the cancer spreads through the body, according to a prominent group of investigators looking for new ways to fight cancer.

Sequencing deer tick genome may help stop Lyme disease one day

Looking for new ways to stop the spread of Lyme disease, a large group of scientists have completed sequencing the genome of the deer tick, which spreads the disease.

Study: LDL, omega-3 nano-strategy eliminates liver cancer cells in rats

There's been a considerable amount of controversy over the past decade whether omega-3 fatty acids can actually promote better health and guard against cancer. But a researcher at UT Southwestern says he has developed a nanoparticle treatment out of LDL and omega-3 that was able to eliminate liver cancer cells in rats while leaving healthy cells unharmed.

Oxford team fingers an inflammatory protein as a trigger for cancer

Researchers from Oxford University working on a protein named PAD4 have made new tracks in identifying its role in cancer, spotlighting a new therapeutic strategy for cancer drug hunters.

NIH researchers find genomic signature common in 5 types of cancer

Scientists hailing from the National Institutes of Health have uncovered genomic signatures that are shared across a number of different cancers. This discovery could serve as a useful biomarker to flag cancer at an earlier stage, paving the way to earlier treatment that may help improve survival rates.

Newcastle University-led investigators link mitochondria to cell aging

As we age, our cells accumulate damage and have increased inflammation. A team of scientists led by Newcastle University's João Passos has found a way to turn back the clock, proving for the first time that mitochondria are triggers of cell aging. When they eliminated the mitochondria from aging lab-grown human cells, the cells displayed characteristics of younger cells.

U.K. scientists get a green light to modify human embryos

Fertilization experts in the U.K. have been given a green light to start modifying human embryos, an experiment which they expect will give them unique insights into the way in which an embryo transforms into a healthy baby.

Gene therapy pioneer James Wilson uses CRISPR/Cas9 to target liver disease

One of the pioneers in the whole gene therapy movement of the past 35 years has combined his knowledge of viral vectors with the hot new CRISPR/Cas9 tech to tackle a rare genetic liver disease. And his work with rodents highlighted both the promise of this new technology as well as an unexpected hurdle.

Researchers discover fusion protein that promotes cancer via three distinct ways in pediatric brain tumors

Scientists at The Children's Hospital of Philadelphia (CHOP) and the Dana Farber Cancer Institute have uncovered an important cancer-driving fusion protein that promotes a pediatric brain tumor via three distinct mechanisms.

Investigators at The Hutch draw up a new battle plan for metastasis

Research coming from the Fred Hutchinson Cancer Research Center and Johns Hopkins Medical Institute concludes that the deadly spreading of cancer occurs in clusters rather than single cancer cells.

Boston Children's team finds potential new melanoma drug target using zebrafish

Why some cancer-prone cells don't ever cross the line into actually becoming malignant is a mystery that has long eluded scientists. Now, researchers at Boston Children's Hospital have answered that question, at least for melanoma. And in doing so, the team visualized for the first time the spread of cancer from a single cell and identified a set of genes as a potential new drug target.

The synNotch solution: UCSF scientists engineer a next-gen T-cell immunotherapy

CAR-T has been all the rage in cancer R&D for several years now as a slate of biotech upstarts pursue highly promising work reengineering T cells into attack weapons by adding a chimeric antigen receptor that can zero in on particular cancer cells. The approach has been highly effective in acute lymphoblastic leukemia, triggering an attack on B cells by homing in on the CD19 antigen, a breakthrough that has inspired a race to the regulatory finish line with the first CAR-Ts.

'The first therapeutic use of CRISPR will be to treat an eye disease'

A cross-country team of investigators at Columbia University Medical Center and the University of Iowa has been doing some preclinical feasibility research into using CRISPR gene editing technology to develop a personalized cure for retinitis pigmentosa, a condition that afflicts some 1.5 million people and eventually leads to blindness.

New molecule targets cancer stem cells

Liang Fang and fellow researchers in Walter Birchmeier's group at the Max Delbrück Center for Molecular Medicine led a team with colleagues at the Berlin-Buch campus which discovered a molecule that interrupts biochemical signals essential for the survival of a "certain type of cancer stem cell."

UT Southwestern team says new liver cancer therapy shows promise in mice

Advanced liver cancer is one of the toughest targets in biotech. But investigators at UT Southwestern say that a dendrimer nanoparticle used to carry microRNA directly to tumor cells has the potential to target the cancer and suppress tumors while sparing surrounding tissue.

Science team says they've taken another step toward a potential cure for diabetes

Building on years of work on developing new insulin-producing cells that could one day control glucose levels and cure diabetes, a group of investigators led by scientists at MIT and Boston Children's Hospital say they've developed a promising new gel capsule that protected the cells from an immune system assault.

Researchers have isolated human monoclonal antibodies that target multiple strains of Ebola

Over the past few years, there has been a surge of research to understand Ebola and develop medicines to stop it. And now researchers at Vanderbilt and the University of Texas have isolated antibodies from Ebola survivors which they say can neutralize multiple species of the virus.

Next-gen approach could help fight pancreatic cancer by altering tumor metabolism

While pancreatic cancer is relatively rare in the U.S., a diagnosis can often mean a death sentence, with the National Cancer Institute pegging the 5-year survival rate at just over 7%. But researchers at the University of Texas Southwestern Medical Center may have found new possibilities for the treatment of pancreatic cancer, starting with CDK4/6 inhibitors.

CHOP scientist fingers a key gene involved in autism

A top genomics expert at the Children's Hospital of Philadelphia (CHOP) says that variations in the RANBP1 gene disrupt brain signaling, offering a new target for subtypes of severe autism and other neurological diseases.

New study offers researchers a guide to making next-gen TB drugs

Drug resistance has been a critical issue in facing the growing threat of tuberculosis around the world. But researchers at Johns Hopkins say that they've unveiled a new way to bolster a current drug class to make them much better at fighting off resistance.