Computer modeling could help design next-generation antibiotics

A team at the University of Bristol in the U.K. used computer simulations to gain insight into how drug-resistant bacteria are able to ward off antibiotics.

Protein boost restores hearing in deaf mice

Zeroing in on a protein that's vital to providing communication between the ears and brain, scientists have restored hearing in mice that were partly deaf. The researchers say that boosting the production of this protein in humans through gene therapy may be able to one day cure people who have lost part or all of their hearing.

GlaxoSmithKline drug flips off cancer mechanism in aggressive leukemia

Turning off an enzyme switch that is needed to activate tumor growth may be an effective way to combat an aggressive kind of cancer called T-cell acute lymphoblastic leukemia, according to researchers at New York University's Langone Medical Center.

Researchers pinpoint potent anti-obesity compounds

Researchers from the National University of Singapore have identified several potent inhibitors that selectively target FTO, a gene that has been associated with fat mass and obesity in certain people.

Human intestinal organoids grown in mice could help personalize treatments

Researchers have grown human intestinal tissue from pluripotent stem cells and transplanted the living tissue into mice. These so-called organoids could provide a more accurate model for testing drugs designed to work on the intestines as well as help generate intestinal tissue for new treatments.

Protein switch could aid recovery after heart attack

By switching on a protein in the heart, scientists may be able to improve recovery in patients that have just endured a heart attack.

Out-of-control neural stem cell growth may play part in autism

A new study appearing in the journal Stem Cell Reports shows that inflammation in pregnant mice causes autism-like symptoms in their offspring.

Alzheimer's 'breakthrough' simulates disease symptoms in brain cells

Investigators have claimed a breakthrough in the amyloid hypothesis, cultivating what they call "Alzheimer's-in-a-dish" that shows deposits of amyloid are indeed to blame for amyloid tangles and brain cell death that lead to the devastating neurodegenerative disease.

Amicus drug improves Parkinson's symptoms in mice

Investigators at the University of California, Los Angeles, have found that a drug being studied for a rare genetic disorder called Gaucher disease also appears to slow the progression of Parkinson's disease in mice.

10 drugs that could stop Ebola

A handful of players are racing to get an Ebola treatment or vaccine to patients as quickly as possible, even though these drugs remain largely untested in humans. We've compiled a list of organizations that are in the global spotlight right now with their investigational Ebola programs.

HIV spikes reveal clues for vaccine development

New technology has allowed researchers to view HIV proteins in action, zooming in on so-called spikes that help the virus bind to cells it infects. The research puts scientists one step closer to a vaccine that could effectively prevent transmission of HIV and halt the spread of AIDS, an international epidemic.

Beta cells produced from stem cells could treat Type 1 diabetes

Scientists from Harvard University have developed a technique that coaxes embryonic stem cells into fully functioning human insulin-producing beta cells, possibly paving the way for less invasive and more permanent treatment options for Type 1 diabetes.

Tetraphase antibiotic candidate kills gram-negative, resistant bacteria

New preclinical results from Tetraphase's lead antibiotic candidate are promising in light of rising drug resistance in dangerous bacteria known as superbugs.

Wellcome Trust, Merck Serono collaborate on cancer drug discovery

Merck Serono is teaming up with London's Institute of Cancer Research and the charitable Wellcome Trust to identify and develop new inhibitors to treat cancer.

NIH doles out first $46M round of BRAIN Initiative grants

President Obama's ambitious BRAIN Initiative--short for Brain Research through Advancing Innovative Neurotechnologies--has awarded its first round of grants, totaling $46 million.

Gene therapy technique could treat rare lung disease

Using a new type of cell transplantation, researchers at Cincinnati Children's Hospital Medical Center corrected a lung disease in mice that mimics a similar rare disease in humans.

Programmed antibiotics kill drug-resistant bacteria

Researchers at Rockefeller University are designing a new kind of antibiotic--one that can be programmed to seek out and kill bad bacteria that harbor antibiotic resistance genes while leaving good microbes in tact.

Ebola genome browser launched to aid drug discovery

The race to develop an effective vaccine or therapy against the ebolavirus is on, with companies large and small answering the World Health Organization's call to ramp up drug discovery efforts.

$19M in FDA grants will support rare disease research

The FDA has awarded 15 grants totaling more than $19 million to spur the development of medical devices and drugs to help treat rare diseases.

Gates Foundation funds monkey study of new HIV vaccine

Swiss firm Mymetics is getting a boost from the Bill and Melinda Gates Foundation to conduct a key animal study for its HIV vaccine candidate at the Texas Biomedical Research Institute.