Antibiotic R&D fell out of favor at Big Pharma companies years ago, chilling a field that only recently has shown signs of heating up with new development projects. But a transatlantic team of investigators electrified the field this week with its claims that a new antibiotic found in dirt was a potent killer of drug-resistant bacteria. And it could represent a new class of badly needed antibiotics that just might avoid the natural resistance that begins to evolve once a new antibiotic hits the market.
In an effort to better understand a certain disease-causing enzyme, British researchers have created a "map" of more than 100 proteins this enzyme is known to affect. They then identified a druglike molecule that blocks this enzyme to preserve these essential proteins.
Scientists at the New York University Langone Medical Center have developed a new technique that uses three familiar compounds, including vitamin C, to generate adult stem cells into pluripotent stem cells at a dramatically more efficient rate--more than 20-fold compared to the current method.
A new strategy that uses broadly neutralizing antibodies combined with a cocktail of viral-inducing compounds may be able to stop HIV from rebounding, according to researchers at Rockefeller University.
A bacteria-based injectable therapy shrunk tumors and completely eradicated others when tested in dogs and rats, according to a new study.
Researchers have used a new drug compound to successfully reverse brain deficits caused by Alzheimer's in animal models. The compound, TC-2153, inhibits the negative effects of a protein called striatal-enriched tyrosine phosphatase--a process that scientists found is key to restoring functions in learning and memory.
British drugmaker GlaxoSmithKline says it is ready to begin clinical trials on an Ebola vaccine later this year and could have the vaccine available by 2015.
An experimental vaccine for Clostridium difficile provided protection in 100% of mice and monkeys that received it. With antibiotic resistance on the rise, the vaccine could be a valuable preventive measure against the infection, which kills about 30,000 Americans every year.
A new discovery of an ancestral fossil virus buried within everyone's genomes might provide the key to eradicating HIV.
Drug development in the Alzheimer's field has been riddled with failures, and many research efforts have focused on pinpointing genetic and environmental factors responsible for causing or accelerating the progression of the disease.