Free Newsletter
Two therapeutic targets identified for metastasis
Scientists at Memorial Sloan-Kettering Cancer Center in New York City have identified the molecular process by which breast cancer cells spread to other tissue during metastasis. A signaling molecule called TGF-beta is one of two new therapeutic targets revealed by the research.
The research team discovered that a signaling relay softened the tissue for an attack by cancer cells, allowing the cancer cells to invade through capillary walls. Ironically, TGF-beta first acts as a tumor suppressor and later assists in metastasis.
"It provides a very nice mechanism for how breast cancer cells specifically get out of the circulation and into the lungs. Nobody knew how they did that before," says Karl Saxe, scientific program director at the American Cancer Society.
- here's the release
- read the article in the Washington Post
Related Article:
A gene for metastasis. Report
Comments
Post new comment
Paid Research Reports
- The Specialty Pharma Market Outlook: Key players, new company growth models and emerging opportunities
- Investigating Clinical Trial Costs: Comparative analysis of trial cost components in key geographies
- Clinical Trial Recruitment Strategies: Optimizing patient recruitment and retention in late stage clinical trials
- Pipeline Insight: Therapeutic Cancer Vaccines - Prospect of first approval set to reinvigorate interest from major companies
- Stakeholder Opinions: Vaccines in Emerging Markets (Asia) - Opportunities in China, India, South Korea and Taiwan
- Big Pharma Performance Before, During and Beyond the Global Recession
