Scientists discover a new aging, lifespan mechanism

Manipulating insulin levels raises the level of the master gene-regulating protein SKN-1, significantly prolonging the lives of microscopic worms in one study. That study could point the way to new therapies for aging and chronic ailments. SKN-1 controls what is called the Phase 2 detoxification pathway, a network of genes that defends cells and tissue against oxidative stress--damage caused by elevated levels of free radicals (byproducts of metabolism)--and various environmental toxins.

"The major implication is that we have found something new that affects lifespan and aging and an important new effect that insulin and/or a related hormone called insulin-like growth factor-1 may have in some tissues," T. Keith Blackwell, M.D., Ph.D., senior investigator at Joslin Diabetes Center and an associate professor of pathology at Harvard Medical School and a faculty member at the Harvard Stem Cell Institute, was quoted as saying. "The implications go far beyond diabetes."

- check out the release for more information

Related Articles:
Genetic mutations slow aging process in centenarians Report
Anti-aging study finds enzymes protect cells. Report
Biotechs pursue anti-aging treatments. Report
Ingredient in wine may boost longevity, health. Report
Longevity gene may be key to living past 100. Report