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Published on FierceBiotech Research (http://www.fiercebiotechresearch.com)

New 'superbug' approach relies on decoy DNA

By admin
Created Dec 4 2007 - 7:59am

A team of scientists in the UK have designed a genetic tool that can disable genes equipped with antibiotic resistance, an approach that could scuttle superbugs like MRSA [1]. And the researchers at John Innes Center have created a spinoff company--Procarta Biosystems--to commercialize their discovery. The key to their work involved taking a stretch of DNA from bacterium that disrupts gene activity and adding it to an antibiotic. The U.S. market for combating antibiotic resistance amounts to $5 billion and is growing as lethal superbugs continue to spread [2].

"The DNA sequence acts as a decoy, disrupting gene expression and blocking resistance," said Michael McArthur, head of the research team. "We are putting genetic information directly into drugs."

- check out the report [3] from the Financial Times

Related Articles:
Dry antibiotic pipeline concerns infectious disease experts. Report [4]
Clues shed light on fighting lethal MRSA strain. Report [5]
Study finds alarming spread of MRSA. Report [6]
Superdrug given wider scope in Europe. Report [7]


Source URL:
http://www.fiercebiotechresearch.com/story/new-superbug-approach-relies-decoy-dna/2007-12-04