Scientists have unveiled yet another study on the potential of resveratrol. The chemical, which is found in red wine [1] as well as a variety of plants [2], has been linked with improved sensitivity to insulin in mouse models, adding another possible therapeutic effect for an ingredient already associated with longevity and DNA repair. Resveratrol activates the SIRT1 enzyme, and researchers at the Chinese Academy of Sciences say that could make it a candidate for treating diabetes. Researchers report that SIRT1 levels are reduced in insulin-resistant cells and tissues and that treatments that block the enzyme's function lead to insulin resistance. Furthermore, increased SIRT1 activity improved insulin sensitivity. Similarly, resveratrol--at a dose of just 2.5 mg/kg/day--enhanced insulin sensitivity in cells. That low dose of resveratrol also reduced insulin resistance in animals fed a high-fat diet, the researchers showed.

"We found SIRT1 improves insulin sensitivity, especially under insulin-resistant conditions," said Chinese scientist Qiwei Zhai. "Furthermore, we found that resveratrol, at a very low dose compared with many previous studies, improves insulin sensitivity via SIRT1."

- see the release [3] on the new resveratrol research

ALSO: OK, says a feature in the Los Angeles Times, resveratrol has been garnering headlines as a wonder tonic. But keep in mind that for now, at least, what we know about the chemical may only be relevant to mice. Report [4]

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