Vitamin B-3 could slow progression of muscle-wasting disorder

Vitamin B-3, or niacin, is an essential human nutrient that has been used for more than 50 years to boost levels of HDL, or good cholesterol, in the blood. Now, new research suggests that a form of the vitamin might also be used to treat adult-onset mitochondrial muscle diseases.

Daiichi Sankyo, UCSF strike deal to combat neurodegeneration

The University of California, San Francisco, is teaming up with Japanese drugmaker Daiichi Sankyo for a drug-discovery pact focused on tackling neurodegenerative diseases.

Lilly, Pfizer partner with Lieber Institute on brain research

The Lieber Institute for Brain Development is partnering with Astellas, Eli Lilly, Lundbeck, Pfizer and Roche to launch an early-stage research consortium to study the genetic mechanisms at work in brain disorders.

Committee finds 'scientific misconduct' in blockbuster stem cell papers

An investigative committee at a leading Japanese research organization has concluded that papers detailing a potential breakthrough in creating embryonic-like stem cells contain falsification and fabrication.

Anticancer compound could reverse symptoms of schizophrenia

Schizophrenia remains a difficult disease to treat, and Johns Hopkins researchers are studying an experimental anticancer compound that may eventually provide relief to patients by reversing symptoms of the devastating mental disorder.

New molecule could provide relief for autoimmune, inflammatory diseases

The discovery of a molecule that coaxes cells to self-destruct may provide a novel way to treat immune disorders and inflammation, according to a new study.

NIH opens largest U.S. neuroscience research center

NIH has completed construction of the second phase of its newest building, the John Edward Porter Neuroscience Research Center, at its campus in Bethesda, MD.

Report: U.S. can do more to support global health R&D

In the midst of flat funding for many federal programs as well as last year's across-the-board spending cuts known as sequestration, global health advocacy groups say Congress needs to adopt a long-term budget solution to sustain R&D activities for new drugs, vaccines and other health technologies to combat global health threats.

Antioxidant could slow progression of Lou Gehrig's disease, extend lifespan

An antioxidant discovered more than a dozen years ago may be able to treat patients with amyotrophic lateral sclerosis, a devastating neurodegenerative disease that is usually fatal within 5 years of diagnosis that currently has no cure.

Knocking out gene reduces fat, extends lifespan in mice

Investigators have identified a gene that appears to play a leading role in coordinating the immune system and metabolism, a finding that could have implications for treating Type 2 diabetes and obesity.

Technique converts stem cells to muscle cells in high volumes

In another step toward using stem cells for regenerative medicine, investigators from the University of Wisconsin-Madison have discovered a new way to make skeletal muscle cells and muscle progenitors in bulk from human pluripotent stem cells.

Amylin diabetes drug improves learning, memory in Alzheimer's mice

A drug developed by Amylin Pharmaceuticals to treat diabetes may also have Alzheimer's-fighting properties, according to a new study.

Antianxiety drugs lessen autism symptoms in mice

Low doses of a well-known class of drugs currently used in much higher doses to treat anxiety and epileptic seizures may be able to treat symptoms of autism, according to new research.

Mushroom-derived compound could stamp out HPV infection

A compound derived from mushrooms may provide a new therapeutic avenue for treating human papillomavirus and curbing HPV-related cancers.

Public-private Japanese partnership invests $15M in infectious diseases

The Japanese Global Health Innovative Technology Fund said it will invest nearly $15 million to advance new drugs for neglected tropical diseases as well as fund the development of a vaccine candidate for tuberculosis.

Capturing leukemic stem cells may help propel new drug discovery

Researchers have identified two new chemical compounds that preserve leukemic stem cells in culture when these are grown outside the body--a major step toward developing new therapies for leukemia.

Study: Chickens, quails are likely to blame for spread of H7N9

Scientists may have cracked the mystery of the origin of the H7N9 avian influenza, which has caused more than 375 infections and 100 deaths. A new study has found that quail and chickens are the likely sources of transmission of H7N9 influenza virus to humans.

Drug derived from snail venom could treat chronic pain with fewer side effects

A tiny protein found in cone snail venom could provide the foundation for a new class of drugs to treat chronic nerve pain, according to scientists.

Compound stops formation of toxic peptides in mice with Alzheimer's

Knocking out a certain gene or reducing its expression by using an enzyme inhibitor may provide a new avenue for treating Alzheimer's disease.

NIH cuts, sequestration hampering cancer research

Years of flat funding from the National Institutes of Health plus across-the-board federal spending cuts known as sequestration could have deleterious effects for cancer research, says a new study by the American Association for Cancer Research.