Technique aims to more accurately test pharmaceuticals

A research team at the University of Texas at Arlington is developing a new technique to test pharmaceuticals for their stability and shelf life that could be 100 times more sensitive than one of the most widely used methods.

Fast-acting antidepressant shows continued relief in animals

A fast-acting antidepressant that provides a mood-lifting effect in mice within 24 hours and continues working for a sustained period may hold promise for use in humans.

Novavax, U. of Maryland report positive preclinical results for MERS vaccine

As the death toll from Middle East respiratory syndrome coronavirus rises in Saudi Arabia, a vaccine designed by Novavax and the University of Maryland has shown promise in blocking the infection in animals.

Deadly MERS outbreak blamed on camels

More evidence points to camels as the likely source of the virus causing the outbreak of Middle East respiratory syndrome, or MERS, which has infected at least 300 people and killed 100 in Saudi Arabia in September 2012.

Protein found in naked mole rats could shed light on Alzheimer's, Parkinson's development

A new study identifying a protein associated with the remarkable longevity of the naked mole rat may provide clues for preventing aging-related diseases in humans, like Alzheimer's and Parkinson's.

Another chink in HIV's armor may point the way to a vaccine

A weakness in the HIV virus exposed by scientists at the Scripps Research Institute and the International AIDS Vaccine Initiative may provide clues for designing a much-sought HIV vaccine.

Rutgers wins $26M NIH grant to help fill lackluster antibiotics pipeline

Rutgers University has landed a $26 million grant from the U.S. National Institute of Allergy and Infectious Diseases to develop new antibiotics to curb the impending crisis of antimicrobial drug resistance.

Preclinical study advances H. pylori vaccine for stomach cancer

Researchers are one step closer to creating a human vaccine for Helicobacter pylori, a bacterium found in 50% of the world's population that infects the stomach and causes chronic gastric inflammation, which can lead to ulcers and stomach cancer.

Single molecule that targets both amyloid and tau could treat Alzheimer's

The Alzheimer's research field has been marked by one failure after another in pursuit of effective treatments, but Cambridge, MA-based NeuroPhage Pharmaceuticals thinks it can tackle the devastating disease with a novel approach.

Experimental drug could thwart measles outbreaks

A new antiviral drug may provide an effective way to treat measles in those who have not been vaccinated.

Cancer stem cells responsible for treatment resistance, cancer relapse

Many drugs used to treat lung, breast and pancreatic cancers also promote drug resistance and can ultimately spur tumor growth. Now, researchers may be able to predict which individual tumors will metastasize and spread when treated with certain drugs.

Mouse model could have predicted drug toxicity that killed 5 in clinical trial

In a 1993 clinical trial of fialuridine--a drug originally designed as a therapy for hepatitis B--5 out of 15 patients died from sudden liver failure. A new study in PLOS Medicine found that mice with humanized livers demonstrate the drug's toxicity.

Improved monitoring of zoonotic diseases could predict future Ebola outbreaks

The ongoing Ebola outbreak in Western Africa underscores the critical need for better global surveillance strategies to combat the emergence of infectious diseases, especially those that have high mortality rates and pose a bioterror threat to countries, according to a new study.

Stabilizing protein complex in brain offers hope for Alzheimer's treatment

A team of investigators has identified a new class of compounds that could work in a specific protein complex in the brain to provide a safe route toward reversing the devastating symptoms of Alzheimer's.

Researchers replicate controversial stem cell-cloning method

Scientists report that they have replicated a method of growing stem cells from adults using cloning techniques--a discovery that could help propel patient-specific regenerative therapies for a myriad of medical conditions and diseases.

Plush 'carpets' of Silly Putty ingredient help stem cells grow

A softer, plusher environment made of a key ingredient in Silly Putty may allow embryonic stem cells to grow faster and produce more specialized cells than traditional methods of making stem cells.

New vaccine could guard against common birth defect-causing virus

An experimental vaccine using a novel defense mechanism could eventually help treat sufferers of a common virus that affects more than half of the U.S. population and causes congenital birth defects in some cases.

3-D printed tumor mimics cancer better than 2-D model

A team of researchers from the U.S. and China has used 3-D printing to create a realistic model of a cancerous tumor.

High protein levels linked to cell death in Parkinson's

Researchers may have discovered how a genetic mechanism in a common cause of Parkinson's works to destroy brain cells in patients--a finding that could help scientists develop new therapies for the devastating disease.

UCSF rolls out patient database to boost brain research

Researchers at the University of California, San Francisco, have launched a new online database to help reduce the time and cost of conducting clinical trials for brain ailments.