High protein levels linked to cell death in Parkinson's

Researchers may have discovered how a genetic mechanism in a common cause of Parkinson's works to destroy brain cells in patients--a finding that could help scientists develop new therapies for the devastating disease.

UCSF rolls out patient database to boost brain research

Researchers at the University of California, San Francisco, have launched a new online database to help reduce the time and cost of conducting clinical trials for brain ailments.

Essential immune organ regenerated in mice

Scottish scientists report that they have successfully regenerated a living mouse organ and transplanted it into a young mouse.

Breast cancer gene BRCA1 linked to brain development

A harmful gene mutation that increases a woman's risk of developing breast and ovarian cancer may also play a role in brain development, according to new findings by scientists at the Salk Institute for Biological Studies.

Study: Fewer clinical trials, less animal research conducted on diseases of the poor

An analysis of nearly 4 million scientific articles has found that drug and disease research is disproportionately focused on medical conditions that predominantly afflict wealthy nations--such as diabetes, cancer and skin diseases--while less attention is given to diseases of the developing countries.

Caffeine-based compound targets tau deposits in Alzheimer's

German and French researchers have found a key clue in how caffeine may work to protect the brain against the devastating effects of Alzheimer's disease.

Vitamin B-3 could slow progression of muscle-wasting disorder

Vitamin B-3, or niacin, is an essential human nutrient that has been used for more than 50 years to boost levels of HDL, or good cholesterol, in the blood. Now, new research suggests that a form of the vitamin might also be used to treat adult-onset mitochondrial muscle diseases.

Daiichi Sankyo, UCSF strike deal to combat neurodegeneration

The University of California, San Francisco, is teaming up with Japanese drugmaker Daiichi Sankyo for a drug-discovery pact focused on tackling neurodegenerative diseases.

Lilly, Pfizer partner with Lieber Institute on brain research

The Lieber Institute for Brain Development is partnering with Astellas, Eli Lilly, Lundbeck, Pfizer and Roche to launch an early-stage research consortium to study the genetic mechanisms at work in brain disorders.

Committee finds 'scientific misconduct' in blockbuster stem cell papers

An investigative committee at a leading Japanese research organization has concluded that papers detailing a potential breakthrough in creating embryonic-like stem cells contain falsification and fabrication.

Anticancer compound could reverse symptoms of schizophrenia

Schizophrenia remains a difficult disease to treat, and Johns Hopkins researchers are studying an experimental anticancer compound that may eventually provide relief to patients by reversing symptoms of the devastating mental disorder.

New molecule could provide relief for autoimmune, inflammatory diseases

The discovery of a molecule that coaxes cells to self-destruct may provide a novel way to treat immune disorders and inflammation, according to a new study.

NIH opens largest U.S. neuroscience research center

NIH has completed construction of the second phase of its newest building, the John Edward Porter Neuroscience Research Center, at its campus in Bethesda, MD.

Report: U.S. can do more to support global health R&D

In the midst of flat funding for many federal programs as well as last year's across-the-board spending cuts known as sequestration, global health advocacy groups say Congress needs to adopt a long-term budget solution to sustain R&D activities for new drugs, vaccines and other health technologies to combat global health threats.

Antioxidant could slow progression of Lou Gehrig's disease, extend lifespan

An antioxidant discovered more than a dozen years ago may be able to treat patients with amyotrophic lateral sclerosis, a devastating neurodegenerative disease that is usually fatal within 5 years of diagnosis that currently has no cure.

Knocking out gene reduces fat, extends lifespan in mice

Investigators have identified a gene that appears to play a leading role in coordinating the immune system and metabolism, a finding that could have implications for treating Type 2 diabetes and obesity.

Technique converts stem cells to muscle cells in high volumes

In another step toward using stem cells for regenerative medicine, investigators from the University of Wisconsin-Madison have discovered a new way to make skeletal muscle cells and muscle progenitors in bulk from human pluripotent stem cells.

Amylin diabetes drug improves learning, memory in Alzheimer's mice

A drug developed by Amylin Pharmaceuticals to treat diabetes may also have Alzheimer's-fighting properties, according to a new study.

Antianxiety drugs lessen autism symptoms in mice

Low doses of a well-known class of drugs currently used in much higher doses to treat anxiety and epileptic seizures may be able to treat symptoms of autism, according to new research.

Mushroom-derived compound could stamp out HPV infection

A compound derived from mushrooms may provide a new therapeutic avenue for treating human papillomavirus and curbing HPV-related cancers.