Three-drug combo kills Ewing sarcoma in mice

A new triple-drug combination therapy tested in mice may provide a new treatment avenue for Ewing sarcoma, a rare bone cancer that primarily affects children and adolescents.

Potential target for triple-negative breast cancer found

Investigators have hit on a potential target for triple-negative breast cancer, a disease that is notoriously impervious to some of the most effective therapies available for breast cancer and has attracted significant interest from drug developers.

Mouse model shows genetics plays a role in Ebola severity

An individual's genetic makeup may be the difference between life and death in patients exposed to the deadly ebolavirus, according to new research.

3D stomach tissue grown from human stem cells

Using human pluripotent stem cells, scientists at Cincinnati Children's Hospital Medical Center have grown functional 3D human stomach tissue for the first time.

Drug combo causes lung cancer cells to self-destruct

U.K. researchers have hit upon a drug combination that appears to combat lung cancer by triggering self-destruction in tumor cells.

Gut bacterium in mosquitoes could combat malaria, dengue

A bacterium found in the gut of an Aedes mosquito may have therapeutic applications for malaria and dengue, two diseases transmitted by these mosquitoes.

Brain cells reprogrammed from skin cells offer treatment hope for Huntington's

Using a new cell programming method, researchers at Washington University in St. Louis have converted human skin cells directly into a type of brain cell that is damaged by Huntington's disease.

Toxin-producing stem cells designed to kill brain tumors

Scientists have figured out a way to harness stem cells so that they can be used to produce and emit toxins capable of killing brain tumors.

Government halts research on dangerous airborne pathogens

The White House is temporarily shutting down biomedical research of dangerous pathogens, such as MERS, SARS and pandemic flu strains following several embarrassing safety incidents at government labs.

Case Western, Janssen, Oncodesign scientists ID anti-inflammatory compounds

Investigators have pegged two compounds that appear to reduce inflammation associated with a wide range of diseases such as ulcerative colitis, arthritis and multiple sclerosis.

Protein discovery could help kill stubborn latent HIV

Researchers at the Salk Institute for Biological Studies have uncovered a protein that plays a role in active HIV replication, essentially acting as part of a switch to turn HIV-1, the most common type of HIV, from a dormant state to an active one.

Computer modeling could help design next-generation antibiotics

A team at the University of Bristol in the U.K. used computer simulations to gain insight into how drug-resistant bacteria are able to ward off antibiotics.

Protein boost restores hearing in deaf mice

Zeroing in on a protein that's vital to providing communication between the ears and brain, scientists have restored hearing in mice that were partly deaf. The researchers say that boosting the production of this protein in humans through gene therapy may be able to one day cure people who have lost part or all of their hearing.

GlaxoSmithKline drug flips off cancer mechanism in aggressive leukemia

Turning off an enzyme switch that is needed to activate tumor growth may be an effective way to combat an aggressive kind of cancer called T-cell acute lymphoblastic leukemia, according to researchers at New York University's Langone Medical Center.

Researchers pinpoint potent anti-obesity compounds

Researchers from the National University of Singapore have identified several potent inhibitors that selectively target FTO, a gene that has been associated with fat mass and obesity in certain people.

Human intestinal organoids grown in mice could help personalize treatments

Researchers have grown human intestinal tissue from pluripotent stem cells and transplanted the living tissue into mice. These so-called organoids could provide a more accurate model for testing drugs designed to work on the intestines as well as help generate intestinal tissue for new treatments.

Protein switch could aid recovery after heart attack

By switching on a protein in the heart, scientists may be able to improve recovery in patients that have just endured a heart attack.

Out-of-control neural stem cell growth may play part in autism

A new study appearing in the journal Stem Cell Reports shows that inflammation in pregnant mice causes autism-like symptoms in their offspring.

Alzheimer's 'breakthrough' simulates disease symptoms in brain cells

Investigators have claimed a breakthrough in the amyloid hypothesis, cultivating what they call "Alzheimer's-in-a-dish" that shows deposits of amyloid are indeed to blame for amyloid tangles and brain cell death that lead to the devastating neurodegenerative disease.

Amicus drug improves Parkinson's symptoms in mice

Investigators at the University of California, Los Angeles, have found that a drug being studied for a rare genetic disorder called Gaucher disease also appears to slow the progression of Parkinson's disease in mice.